Profile Response Detail

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Molecular Profile ALK fusion
Therapy Crizotinib
Indication/Tumor Type inflammatory myofibroblastic tumor
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK fusion inflammatory myofibroblastic tumor sensitive Crizotinib FDA approved Actionable In a Phase I/II trial (Study ADVL0912) that supported FDA approval, Xalkori (crizotinib) therapy was safe and resulted in an objective response rate of 86% (12/14, 5 complete responses, 7 partial responses) and stable disease in 14% (2/14) of pediatric patients with ALK-positive unresectable inflammatory myofibroblastic tumors, with a median duration of response of 1.63 years (PMID: 28787259; NCT00939770). detail... 28787259
ALK fusion inflammatory myofibroblastic tumor sensitive Crizotinib FDA approved Actionable In a Phase Ib trial (PROFILE 1013) that supported FDA approval, treatment with Xalkori (crizotinib) resulted in an objective response rate of 66.7% (6/9, 1 complete response, 5 partial responses) and stable disease in 33.3% (3/9) of adult patients with advanced ALK-positive inflammatory myofibroblastic tumors, with a median duration of response of 74.1 weeks in (PMID: 29352732; NCT00939770). 29352732 detail...
PubMed Id Reference Title Details
(28787259) Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study. Full reference...
Xalkori (crizotinib) FDA Drug Label Full reference...
Xalkori (crizotinib) FDA Drug Label Full reference...
(29352732) Long-term effects of crizotinib in ALK-positive tumors (excluding NSCLC): A phase 1b open-label study. Full reference...