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| Molecular Profile | ARID1A mutant |
| Therapy | VE-821 |
| Indication/Tumor Type | ovarian clear cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ARID1A mutant | ovarian clear cell carcinoma | sensitive | VE-821 | Preclinical - Cell culture | Actionable | In a preclinical study, ovarian clear cell carcinoma cells harboring an ARID1A mutation were sensitive to VE-821 in in vitro assays, demonstrating decreased cell survival (PMID: 27958275). | 27958275 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27958275) | ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. | Full reference... |