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| Molecular Profile | ARID1A Q456* |
| Therapy | Berzosertib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ARID1A Q456* | colorectal cancer | sensitive | Berzosertib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Berzosertib (VX-970) treatment in colorectal cancer cells homozygous for ARID1A Q456* resulted in decreased cell survival in culture, and tumor growth inhibition in cell line xenograft models (PMID: 27958275). | 27958275 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27958275) | ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. | Full reference... |