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| Molecular Profile | BRAF V600E KEAP1 loss |
| Therapy | Trametinib |
| Indication/Tumor Type | lung cancer |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E KEAP1 loss | lung cancer | decreased response | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, KEAP1 knockout resulted in decreased sensitivity to Mekinist (trametinib) in a lung cancer cell line harboring BRAF V600E in culture (PMID: 28145866). | 28145866 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28145866) | KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. | Full reference... |