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Profile Name | BRAF V600E KEAP1 loss |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
BRAF V600E KEAP1 loss | lung cancer | decreased response | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, KEAP1 knockout resulted in decreased sensitivity to Mekinist (trametinib) in a lung cancer cell line harboring BRAF V600E in culture (PMID: 28145866). | 28145866 | |
BRAF V600E KEAP1 loss | lung cancer | decreased response | Vemurafenib | Preclinical - Cell culture | Actionable | In a preclinical study, KEAP1 knockout resulted in decreased sensitivity to Zelboraf (vemurafenib) in a lung cancer cell line harboring BRAF V600E in culture (PMID: 28145866). | 28145866 |