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| Molecular Profile | PDGFRB N666H |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PDGFRB N666H | Advanced Solid Tumor | sensitive | Imatinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Gleevec (imatinib mesylate) inhibited Pdgfrb phosphorylation, resulting in growth inhibition of transformed cells overexpressing PDGFRB N666H and in primary cells derived from a patient harboring germline PDGFRB N666H (PMID: 28726812). | 28726812 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28726812) | A patient with germ-line gain-of-function PDGFRB p.N666H mutation and marked clinical response to imatinib. | Full reference... |