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Molecular Profile | KIT V560del |
Therapy | G007-LK + Imatinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560del | gastrointestinal stromal tumor | sensitive | G007-LK + Imatinib | Preclinical | Actionable | In a preclinical study, the combination of G007-LK and Gleevec (imatinib) demonstrated increased anti-tumor activity compared to either agent alone in a mouse model of gastrointestinal stromal tumor expressing Kit V558del (corresponding to human V560del) (PMID: 28611108). | 28611108 |
PubMed Id | Reference Title | Details |
---|---|---|
(28611108) | Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor. | Full reference... |