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ID | DOID:9253 |
Name | gastrointestinal stromal tumor |
Definition | |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer gastrointestinal stromal tumor |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
KIT amp | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K642E | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT positive | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT act mut | Cabozantinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT act mut | Pexidartinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560D KIT D820A | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT V560D KIT D820A | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT mutant | N/A | gastrointestinal stromal tumor | not applicable | detail... |
KIT exon9 | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT T670I | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560_L576del | Ponatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_L576del | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Ponatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_L576del KIT V654A | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT T670I | Ponatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT T670I | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT D816E | Sunitinib | gastrointestinal stromal tumor | decreased response | detail... |
KIT V560_Y578del KIT A829P | Sunitinib | gastrointestinal stromal tumor | decreased response | detail... |
KIT K642E | Ponatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT N822K | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT Y823D | Ponatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557C KIT K558_V560del | Ponatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT P551_W557delinsL | Ponatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT M552_K558del | Ponatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del | PD-0325901 | gastrointestinal stromal tumor | sensitive | detail... |
KIT K642E | Imatinib + Infigratinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Imatinib + Infigratinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT mutant | Imatinib + Infigratinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT Y823D | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Ponatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 | Dasatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 | Nilotinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT P551_V555del | Sorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT P551_V555delinsTL | Sorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K558_G565delinsR | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT A502_Y503dup | Imatinib | gastrointestinal stromal tumor | conflicting | detail... |
KIT W557Lfs*5 KIT P577del KIT D820G | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT K558_G565delinsR | Cabozantinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT A502_Y503dup | Cabozantinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557Lfs*5 KIT P577del KIT D820G | Cabozantinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Imatinib + MK2206 | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 KIT A829P | Imatinib + MK2206 | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 KIT V654A | Imatinib + MK2206 | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon13 | Imatinib + MK2206 | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon17 | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT mutant | Ripretinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon 11 del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 | Imatinib + PKF118-310 | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | Imatinib + XAV939 | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560del | G007-LK + Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT Y823D | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_V559delinsF | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT V654A | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT D820V | Avapritinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT act mut | N/A | gastrointestinal stromal tumor | not applicable | detail... |
KIT Y570_L576del KIT D816E PTEN T321fs | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT Y570_L576del KIT D816E PTEN T321fs | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT Y570_L576del KIT D816E PTEN T321fs | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 KIT T670I | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon11 KIT T670I | Sunitinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 KIT T670I | Regorafenib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT A502_Y503dup KIT D820E | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT A502_Y503dup KIT D820E | Sunitinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT A502_Y503dup | Regorafenib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT Y570_L576del KIT D816E PTEN T321fs | Imatinib + LY294002 | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | PLX9486 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon17 | PLX9486 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 | Pexidartinib + PLX9486 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon17 | Pexidartinib + PLX9486 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 KIT exon17 | PLX9486 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT W557Lfs*5 KIT P577del KIT D820G | PLX9486 | gastrointestinal stromal tumor | sensitive | detail... |
KIT D820N | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT D816E KIT D820V | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V555_L576del KIT D820G KIT D820Y | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT A502_Y503dup KIT N822K | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K558_V560del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558delinsCE KIT N822K | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V559A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V569_L576del KIT V654A KIT N822K | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT Y553S KIT W557_Q575del KIT D820Y | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT mutant | Avapritinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V560_Y578del KIT V654A | AZD3229 | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT V654A | AZD3229 | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT Y823D | AZD3229 | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Olverembatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon9 | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Axitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K642E | Axitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT T670I | Axitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V559D | Axitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K642E | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V654A | Avapritinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT T670I | Avapritinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560D | Avapritinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon 11 del | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del | Midostaurin | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT T670I | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT exon 11 del KIT T670I | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT T670I | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT T670I | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT T670I | Midostaurin | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT T670I | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D816E | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D816E | Midostaurin | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D816E | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D816E | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT D816E | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D816E | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V559_G565del KIT V654A KIT A829P | Ripretinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT Y568_L576delinsCV KIT D816E KIT D820Y | Ripretinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
CDKN2A del | Palbociclib | gastrointestinal stromal tumor | no benefit | detail... |
KIT V560_L576del KIT V654A | Olverembatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557Lfs*5 KIT P577del KIT D820G | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT A502_Y503dup | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K642E KIT C809G KIT N822H | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K642E KIT N822K | AZD3229 | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT Y823D | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K642E KIT N822K | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT V654A | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT V654A | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT V654A | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560_Y578del KIT V654A | Avapritinib | gastrointestinal stromal tumor | resistant | detail... |
KIT V560_Y578del KIT V654A | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT V560_Y578del KIT V654A | Regorafenib | gastrointestinal stromal tumor | resistant | detail... |
KIT V560_Y578del | AZD3229 | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT V560_Y578del | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon9 | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon9 | Imatinib + Infigratinib | gastrointestinal stromal tumor | no benefit | detail... |
KIT exon11 | Imatinib + Infigratinib | gastrointestinal stromal tumor | no benefit | detail... |
KIT W557_K558del KIT Y823D | PLX9486 | gastrointestinal stromal tumor | sensitive | detail... |
KIT N655K | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon 11 del | Adavosertib + Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon13 | Adavosertib + Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del | Adavosertib | gastrointestinal stromal tumor | no benefit | detail... |
KIT V560_Y578del | Copanlisib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Copanlisib + Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT T670I | Copanlisib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 KIT V654A | Copanlisib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 KIT V654A | Copanlisib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V560_Y578del KIT T670I | Copanlisib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT W557_E561del | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_E561del | Imatinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_L576del KIT V654A | Imatinib | gastrointestinal stromal tumor | resistant | detail... |
KIT V560_L576del KIT V654A | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del | THE-630 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT A502_Y503dup | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT K558_V559del | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT E562_L576del | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V560D | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT E554_K558del | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT W557_K558del KIT N822K | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT Q556_I571del KIT V654A | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT Q556_V559delinsHT KIT V654A | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560D KIT D820G KIT N822K KIT Y870* | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT E562_L576del KIT N822Y | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT E554_K558del KIT V654A | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT exon9 | Regorafenib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_L576del | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V560_Y578del KIT T670I | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT V559D | Nintedanib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT K642E | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT K509I | Imatinib | gastrointestinal stromal tumor | no benefit | detail... |
KIT V560E | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT K642E | IDRX-42 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT W557Lfs*5 KIT P577del KIT D820G | IDRX-42 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT A502_Y503dup | IDRX-42 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
PIK3CA L10_P18del PIK3CA E545K | Alpelisib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon9 | Ponatinib | gastrointestinal stromal tumor | no benefit | detail... |
KIT E554_Y570del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT E554_Y570del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT W557_K558del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT T670I | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT D816H | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT Y823D | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_E561del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_E561del KIT N822D | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT M552_D572del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT M552_D572del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V560del KIT N822K | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V555_D572del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V555_D572del KIT N822K | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V555_D572del KIT N822Y | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT P551I KIT M552_V559del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT P551I KIT M552_V559del KIT Y823D | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560_D572del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V560_D572del KIT A829P | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V559_T574del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V559_T574del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K558N KIT V560del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT Y570_Y578del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT Q556_W557del | Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT Q556_W557del KIT V654A | Imatinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V560D KIT D820A | Imatinib + Infigratinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT W557Lfs*5 KIT P577del KIT D820G | Dovitinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT A502_Y503dup | Binimetinib + Dovitinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT A502_Y503dup | Dovitinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
BRAF V600E | Dabrafenib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT V560del | Binimetinib + Imatinib | gastrointestinal stromal tumor | predicted - sensitive | detail... |
BRAF V600E | Dabrafenib + Trametinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 KIT exon13 | DCC-3009 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon11 KIT exon17 | DCC-3009 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon 11 del KIT V654A | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A KIT D816A | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A KIT D820A | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A KIT N822K | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A KIT A829P | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT N822K | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D816A | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT A829P | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT C809G | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D820A | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D820Y | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT A502_Y503dup | Ripretinib | gastrointestinal stromal tumor | resistant | detail... |
KIT A502_Y503dup KIT N822K | Ripretinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT N822K | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT D816A | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT A829P | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT D820A | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT D820Y | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT A502_Y503dup | Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT A502_Y503dup KIT N822K | Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT N560_Y574del KIT V654A | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT V654A | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT M552_E554delinsK KIT V654A | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT V559_E561del KIT T670I | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT V654A KIT D820V | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K558_V559delinsN KIT T670E | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT Q556_V559delinsH KIT T670I | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT A502_Y503dup KIT T574_P577del KIT V654A KIT N822K | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K642E KIT N822Y | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K550_K558del KIT V654A KIT A829P | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT Q556_K558delinsE KIT V654A KIT Y823H | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT W557_K558del KIT V654G KIT D816H | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT K550_V555del KIT V654A KIT C809G | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT Q556_V559delinsH KIT Y823D | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT P551_E554delinsQ KIT S645_L647dup KIT D820Y | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT exon 11 del | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT A502_Y503dup | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D820A | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT T670I | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D820Y | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A KIT D820A | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A KIT A829P | Nintedanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A | Nintedanib | gastrointestinal stromal tumor | decreased response | detail... |
KIT exon 11 del KIT V654A KIT D820A | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A KIT N822K | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A KIT A829P | Avapritinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A KIT D820A | Crenolanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT V654A KIT A829P | Crenolanib | gastrointestinal stromal tumor | sensitive | detail... |
KIT W557_K558del KIT V654A KIT I748D | Ripretinib | gastrointestinal stromal tumor | predicted - resistant | detail... |
KIT exon 11 del KIT V654A KIT D816A | Ripretinib + Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A KIT D820A | Ripretinib + Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A KIT A829P | Ripretinib + Sunitinib | gastrointestinal stromal tumor | resistant | detail... |
KIT exon 11 del KIT V654A | Ripretinib + Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon 11 del KIT D820A | Ripretinib + Sunitinib | gastrointestinal stromal tumor | sensitive | detail... |
KIT exon11 | IDRX-42 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon9 | IDRX-42 | gastrointestinal stromal tumor | predicted - sensitive | detail... |
KIT exon9 | Imatinib + Spartalizumab | gastrointestinal stromal tumor | no benefit | detail... |
KIT exon11 | Imatinib + Spartalizumab | gastrointestinal stromal tumor | no benefit | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT00290485 | Phase II | Imatinib | Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST) | Unknown status | CAN | 0 |
NCT00812240 | Phase III | Masitinib Imatinib | A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Comparison to Imatinib in Patients With Gastro-Intestinal Stromal Tumour in First Line Medical Treatment | Terminated | USA | LBN | FRA | 0 |
NCT01396148 | Phase II | Sunitinib | A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor | Completed | USA | FRA | CZE | 0 |
NCT01643278 | Phase I | Dasatinib + Ipilimumab | Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic | Completed | USA | 0 |
NCT01738139 | Phase I | Imatinib + Ipilimumab | Ipilimumab and Imatinib Mesylate in Advanced Cancer | Completed | USA | 0 |
NCT01874665 | Phase II | Ponatinib | A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor | Completed | USA | 0 |
NCT01991379 | Phase Ib/II | Binimetinib + Imatinib | MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) | Active, not recruiting | USA | 0 |
NCT02015065 | Phase II | Vandetanib | Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors | Completed | USA | 0 |
NCT02034110 | Phase II | Dabrafenib + Trametinib | Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers | Completed | USA | SWE | NOR | NLD | ITA | FRA | ESP | DNK | DEU | CAN | BEL | AUT | 2 |
NCT02071862 | Phase I | Everolimus + Telaglenastat Erlotinib + Telaglenastat Docetaxel + Telaglenastat Telaglenastat Paclitaxel + Telaglenastat Cabozantinib + Telaglenastat | Study of the Glutaminase Inhibitor CB-839 in Solid Tumors | Completed | USA | 0 |
NCT02122809 | Phase I | Chiauranib | Phase I Study of Chiauranib in Patients With Advanced Solid Tumors | Completed | 1 | |
NCT02164240 | Phase I | Sunitinib Regorafenib | Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST | Completed | USA | 0 |
NCT02232620 | Phase II | Amcasertib | A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors | Terminated | CAN | 0 |
NCT02257541 | Phase Ib/II | Imatinib + Infigratinib | BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) | Completed | USA | 0 |
NCT02260505 | Phase III | Imatinib | Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (ImadGist) | Completed | FRA | 0 |
NCT02401815 | Phase Ib/II | PLX9486 + Sunitinib Pexidartinib + PLX9486 PLX9486 | PLX9486 as a Single Agent and in Combination With PLX3397 or PLX9486 With Sunitinib in Patients With Advanced Solid Tumors | Completed | USA | 0 |
NCT02406781 | Phase II | Cyclophosphamide + Pembrolizumab Cyclophosphamide + GLA-SE + Pembrolizumab | Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial (PEMBROSARC) | Unknown status | FRA | 0 |
NCT02508532 | Phase I | Avapritinib | Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors | Completed | USA | POL | NLD | ITA | GBR | FRA | ESP | DEU | BEL | 1 |
NCT02574663 | Phase I | Gemcitabine + Nab-paclitaxel Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Umbralisib | TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors | Completed | USA | 0 |
NCT02638766 | Phase II | Regorafenib | Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST (REGISTRI) | Completed | ITA | FRA | ESP | 0 |
NCT02847429 | Phase III | Crenolanib | Randomized Trial of Crenolanib in Subjects With D842V Mutated GIST | Unknown status | USA | POL | NOR | ITA | FRA | ESP | DEU | 0 |
NCT02880020 | Phase II | Nivolumab Ipilimumab + Nivolumab | Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery | Completed | USA | 0 |
NCT02992912 | Phase II | Atezolizumab | Atezolizumab With Stereotactic Ablative Radiotherapy in Patients With Metastatic Tumours (SABR-PDL1) | Active, not recruiting | FRA | 0 |
NCT03109301 | Phase II | Selumetinib | A Phase II Trial of the Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Patients With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) | Withdrawn | 0 | |
NCT03158103 | Phase I | Binimetinib + Pexidartinib | A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) | Completed | USA | 0 |
NCT03165721 | Phase II | Guadecitabine | A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer | Terminated | USA | 0 |
NCT03291054 | Phase II | Epacadostat + Pembrolizumab | Epacadostat and Pembrolizumab in Patients With GIST | Terminated | USA | 0 |
NCT03353753 | Phase III | Ripretinib | Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies (invictus) | Completed | USA | POL | NLD | ITA | GBR | FRA | FIN | ESP | DEU | CAN | BEL | AUS | 1 |
NCT03411915 | Phase I | XmAb18087 | A Study of XmAb18087 in Subjects With NET and GIST | Completed | USA | 0 |
NCT03465722 | Phase III | Regorafenib Avapritinib | (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST | Completed | USA | SWE | POL | NLD | ITA | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BEL | AUT | AUS | 3 |
NCT03475953 | Phase Ib/II | Avelumab + Regorafenib | A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors (REGOMUNE) | Recruiting | FRA | 0 |
NCT03556384 | Phase II | Temozolomide | Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) | Active, not recruiting | USA | 0 |
NCT03673501 | Phase III | Sunitinib Ripretinib | A Study of DCC-2618 vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib (intrigue) | Active, not recruiting | USA | SWE | POL | NOR | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BEL | AUS | ARG | 4 |
NCT04000529 | Phase I | Spartalizumab + TNO155 Ribociclib + TNO155 | Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies | Terminated | USA | ESP | DEU | BEL | AUS | 4 |
NCT04138381 | Phase Ib/II | Imatinib + Selinexor | Selinexor as a Single Agent and in Combination With Imatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors. (SeliGIST) | Active, not recruiting | ESP | 0 |
NCT04193553 | Phase II | Lenvatinib | Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure (LENVAGIST) | Completed | FRA | 0 |
NCT04276415 | Phase I | DS-6157a | DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST) | Terminated | USA | 1 |
NCT04530981 | Phase I | Repaglinide + Ripretinib | A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients With Advanced GIST | Completed | USA | 0 |
NCT04595747 | Phase II | Rogaratinib | Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST) | Active, not recruiting | USA | 0 |
NCT04714983 | Phase I | DNX-2440 | DNX-2440 for Resectable Colorectal Liver Metastasis | Suspended | USA | 0 |
NCT04908176 | Phase I | Avapritinib + Midazolam | A Drug-drug Interaction Study of Avapritinib and Midazolam | Active, not recruiting | USA | 0 |
NCT04936178 | Phase I | NB003 | A Study of NB003 in Patients With Advanced Malignancies | Recruiting | USA | GBR | FRA | ESP | 2 |
NCT05006794 | Phase I | GS-9716 + Sacituzumab govitecan-hziy GS-9716 Docetaxel + GS-9716 | Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies | Recruiting | USA | ISR | 0 |
NCT05009927 | Phase II | Imatinib | Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten) | Recruiting | FRA | 0 |
NCT05080621 | Phase Ib/II | Binimetinib + Ripretinib | Ripretinib in Combination With Binimetinib in Patients With Gastrointestinal Stromal Tumor (GIST) | Withdrawn | 0 | |
NCT05152472 | Phase II | Imatinib Atezolizumab + Imatinib | A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments (ATEZOGIST) | Recruiting | FRA | 0 |
NCT05160168 | Phase Ib/II | THE-630 | A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) | Terminated | USA | 0 |
NCT05208047 | Phase III | Sunitinib PLX9486 + Sunitinib PLX9486 | (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors | Recruiting | USA | SWE | POL | NOR | NLD | ITA | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | AUS | ARG | 5 |
NCT05245968 | Phase I | Imatinib Sunitinib Pimitespib Imatinib + Pimitespib | A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101) | Recruiting | AUS | 4 |
NCT05366816 | Phase II | Regorafenib Sunitinib | ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST | Recruiting | USA | 0 |
NCT05489237 | Phase I | IDRX-42 | A First-in-human (FIH) Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) [Study ID: StrateGIST 1] | Recruiting | USA | ESP | DEU | BEL | 0 |
NCT05493215 | Phase II | Imatinib | Imatinib TDM in GIST | Recruiting | USA | 0 |
NCT05734105 | Phase III | Ripretinib Sunitinib | A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib (INSIGHT) | Recruiting | USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BRA | AUS | 3 |
NCT05957367 | Phase Ib/II | DCC-3116 + Ripretinib Cetuximab + DCC-3116 + Encorafenib | A Study of DCC-3116 in Combination With Anticancer Therapies in Participants With Advanced Malignancies | Recruiting | USA | 0 |
NCT06087263 | Phase II | Regorafenib | Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting. | Recruiting | USA | 0 |
NCT06208748 | Phase II | PLX9486 + Sunitinib | SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST | Recruiting | USA | 0 |
NCT06630234 | Phase Ib/II | DCC-3009 | A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST) | Recruiting | USA | 0 |