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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT amp Imatinib gastrointestinal stromal tumor sensitive detail...
KIT K642E Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT positive Imatinib gastrointestinal stromal tumor sensitive detail...
KIT act mut Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT act mut Pexidartinib gastrointestinal stromal tumor sensitive detail...
KIT V560D KIT D820A Imatinib gastrointestinal stromal tumor resistant detail...
KIT V560D KIT D820A Sunitinib gastrointestinal stromal tumor resistant detail...
KIT mutant N/A gastrointestinal stromal tumor not applicable detail...
KIT exon9 Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT T670I Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560_L576del Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT D816E Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT V560_Y578del KIT A829P Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT K642E Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT Y823D Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT W557C KIT K558_V560del Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT P551_W557delinsL Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT M552_K558del Ponatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del PD-0325901 gastrointestinal stromal tumor sensitive detail...
KIT K642E Imatinib + Infigratinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Imatinib + Infigratinib gastrointestinal stromal tumor sensitive detail...
KIT mutant Imatinib + Infigratinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Imatinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Dasatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Nilotinib gastrointestinal stromal tumor sensitive detail...
KIT P551_V555del Sorafenib gastrointestinal stromal tumor sensitive detail...
KIT P551_V555delinsTL Sorafenib gastrointestinal stromal tumor sensitive detail...
KIT K558_G565delinsR Imatinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Imatinib gastrointestinal stromal tumor conflicting detail...
KIT W557Lfs*5 KIT P577del KIT D820G Imatinib gastrointestinal stromal tumor resistant detail...
KIT K558_G565delinsR Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT A829P Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT V654A Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon13 Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon17 Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT mutant Ripretinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Imatinib + PKF118-310 gastrointestinal stromal tumor sensitive detail...
KIT exon11 Imatinib + XAV939 gastrointestinal stromal tumor sensitive detail...
KIT V560del G007-LK + Imatinib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT W557_V559delinsF Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT D820V Avapritinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT act mut N/A gastrointestinal stromal tumor not applicable detail...
KIT Y570_L576del KIT D816E PTEN T321fs Imatinib gastrointestinal stromal tumor resistant detail...
KIT Y570_L576del KIT D816E PTEN T321fs Sunitinib gastrointestinal stromal tumor resistant detail...
KIT Y570_L576del KIT D816E PTEN T321fs Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT T670I Imatinib gastrointestinal stromal tumor resistant detail...
KIT exon11 KIT T670I Sunitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 KIT T670I Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup KIT D820E Imatinib gastrointestinal stromal tumor resistant detail...
KIT A502_Y503dup KIT D820E Sunitinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT Y570_L576del KIT D816E PTEN T321fs Imatinib + LY294002 gastrointestinal stromal tumor sensitive detail...
KIT exon11 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon17 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Pexidartinib + PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon17 Pexidartinib + PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 KIT exon17 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G PLX9486 gastrointestinal stromal tumor sensitive detail...
KIT D820N Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT D816E KIT D820V Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V555_L576del KIT D820G KIT D820Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K558_V560del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558delinsCE KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V559A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V569_L576del KIT V654A KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Y553S KIT W557_Q575del KIT D820Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT mutant Avapritinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560_Y578del KIT V654A AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Olverembatinib gastrointestinal stromal tumor sensitive detail...
KIT exon9 Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Axitinib gastrointestinal stromal tumor sensitive detail...
KIT K642E Axitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Axitinib gastrointestinal stromal tumor sensitive detail...
KIT V559D Axitinib gastrointestinal stromal tumor sensitive detail...
KIT K642E Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V654A Avapritinib gastrointestinal stromal tumor predicted - resistant detail...
KIT T670I Avapritinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560D Avapritinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 del Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Midostaurin gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT exon 11 del KIT T670I Imatinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT T670I Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Midostaurin gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Midostaurin gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT D816E Imatinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT V559_G565del KIT V654A KIT A829P Ripretinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT Y568_L576delinsCV KIT D816E KIT D820Y Ripretinib gastrointestinal stromal tumor predicted - sensitive detail...
CDKN2A del Palbociclib gastrointestinal stromal tumor no benefit detail...
KIT V560_L576del KIT V654A Olverembatinib gastrointestinal stromal tumor sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT K642E KIT C809G KIT N822H Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K642E KIT N822K AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT K642E KIT N822K Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT V654A Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560_Y578del KIT V654A Avapritinib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del KIT V654A Imatinib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del KIT V654A Regorafenib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Ripretinib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon9 Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon9 Imatinib + Infigratinib gastrointestinal stromal tumor no benefit detail...
KIT exon11 Imatinib + Infigratinib gastrointestinal stromal tumor no benefit detail...
KIT W557_K558del KIT Y823D PLX9486 gastrointestinal stromal tumor sensitive detail...
KIT N655K Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 del Adavosertib + Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon13 Adavosertib + Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Adavosertib gastrointestinal stromal tumor no benefit detail...
KIT V560_Y578del Copanlisib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Copanlisib + Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Copanlisib gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT V654A Copanlisib gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT V654A Copanlisib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560_Y578del KIT T670I Copanlisib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557_E561del Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT W557_E561del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del KIT V654A Imatinib gastrointestinal stromal tumor resistant detail...
KIT V560_L576del KIT V654A Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del THE-630 gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup Binimetinib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT K558_V559del Binimetinib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT E562_L576del Binimetinib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560D Binimetinib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT E554_K558del Binimetinib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557_K558del KIT N822K Binimetinib + Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Q556_I571del KIT V654A Binimetinib + Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Q556_V559delinsHT KIT V654A Binimetinib + Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560D KIT D820G KIT N822K KIT Y870* Binimetinib + Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT E562_L576del KIT N822Y Binimetinib + Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT E554_K558del KIT V654A Binimetinib + Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT exon9 Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT V559D Nintedanib gastrointestinal stromal tumor predicted - sensitive detail...
KIT K642E Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT K509I Imatinib gastrointestinal stromal tumor no benefit detail...
KIT V560E Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT K642E IDRX-42 gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G IDRX-42 gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup IDRX-42 gastrointestinal stromal tumor predicted - sensitive detail...
PIK3CA L10_P18del PIK3CA E545K Alpelisib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon9 Ponatinib gastrointestinal stromal tumor no benefit detail...
KIT E554_Y570del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT E554_Y570del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557_K558del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT T670I Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT D816H Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT Y823D Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_E561del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_E561del KIT N822D Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT M552_D572del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT M552_D572del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560del KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V555_D572del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V555_D572del KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V555_D572del KIT N822Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT P551I KIT M552_V559del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT P551I KIT M552_V559del KIT Y823D Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560_D572del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560_D572del KIT A829P Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V559_T574del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V559_T574del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K558N KIT V560del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT Y570_Y578del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT Q556_W557del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT Q556_W557del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560D KIT D820A Imatinib + Infigratinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G Dovitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup Binimetinib + Dovitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup Dovitinib gastrointestinal stromal tumor predicted - sensitive detail...
BRAF V600E Dabrafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560del Binimetinib + Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
BRAF V600E Dabrafenib + Trametinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT exon13 DCC-3009 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 KIT exon17 DCC-3009 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 del KIT V654A Ripretinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A KIT D816A Ripretinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A KIT D820A Ripretinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A KIT N822K Ripretinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A KIT A829P Ripretinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT N822K Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816A Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT A829P Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT C809G Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D820A Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D820Y Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Ripretinib gastrointestinal stromal tumor resistant detail...
KIT A502_Y503dup KIT N822K Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT N822K Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT D816A Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT A829P Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT D820A Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT D820Y Sunitinib gastrointestinal stromal tumor resistant detail...
KIT A502_Y503dup Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup KIT N822K Sunitinib gastrointestinal stromal tumor resistant detail...
KIT N560_Y574del KIT V654A Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT V654A Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT M552_E554delinsK KIT V654A Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V559_E561del KIT T670I Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT V654A KIT D820V Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K558_V559delinsN KIT T670E Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Q556_V559delinsH KIT T670I Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup KIT T574_P577del KIT V654A KIT N822K Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K642E KIT N822Y Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K550_K558del KIT V654A KIT A829P Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Q556_K558delinsE KIT V654A KIT Y823H Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT V654G KIT D816H Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K550_V555del KIT V654A KIT C809G Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Q556_V559delinsH KIT Y823D Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT P551_E554delinsQ KIT S645_L647dup KIT D820Y Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT exon 11 del Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D820A Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D820Y Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A KIT D820A Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A KIT A829P Nintedanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A Nintedanib gastrointestinal stromal tumor decreased response detail...
KIT exon 11 del KIT V654A KIT D820A Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A KIT N822K Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A KIT A829P Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A KIT D820A Crenolanib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT V654A KIT A829P Crenolanib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A KIT I748D Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT exon 11 del KIT V654A KIT D816A Ripretinib + Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A KIT D820A Ripretinib + Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A KIT A829P Ripretinib + Sunitinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT V654A Ripretinib + Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D820A Ripretinib + Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 IDRX-42 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon9 IDRX-42 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon9 Imatinib + Spartalizumab gastrointestinal stromal tumor no benefit detail...
KIT exon11 Imatinib + Spartalizumab gastrointestinal stromal tumor no benefit detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00290485 Phase II Imatinib Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST) Unknown status CAN 0
NCT00812240 Phase III Masitinib Imatinib A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Comparison to Imatinib in Patients With Gastro-Intestinal Stromal Tumour in First Line Medical Treatment Terminated USA | LBN | FRA 0
NCT01396148 Phase II Sunitinib A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor Completed USA | FRA | CZE 0
NCT01643278 Phase I Dasatinib + Ipilimumab Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic Completed USA 0
NCT01738139 Phase I Imatinib + Ipilimumab Ipilimumab and Imatinib Mesylate in Advanced Cancer Completed USA 0
NCT01874665 Phase II Ponatinib A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Completed USA 0
NCT01991379 Phase Ib/II Binimetinib + Imatinib MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) Active, not recruiting USA 0
NCT02015065 Phase II Vandetanib Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors Completed USA 0
NCT02034110 Phase II Dabrafenib + Trametinib Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers Completed USA | SWE | NOR | NLD | ITA | FRA | ESP | DNK | DEU | CAN | BEL | AUT 2
NCT02071862 Phase I Everolimus + Telaglenastat Erlotinib + Telaglenastat Docetaxel + Telaglenastat Telaglenastat Paclitaxel + Telaglenastat Cabozantinib + Telaglenastat Study of the Glutaminase Inhibitor CB-839 in Solid Tumors Completed USA 0
NCT02122809 Phase I Chiauranib Phase I Study of Chiauranib in Patients With Advanced Solid Tumors Completed 1
NCT02164240 Phase I Sunitinib Regorafenib Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST Completed USA 0
NCT02232620 Phase II Amcasertib A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors Terminated CAN 0
NCT02257541 Phase Ib/II Imatinib + Infigratinib BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) Completed USA 0
NCT02260505 Phase III Imatinib Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (ImadGist) Completed FRA 0
NCT02401815 Phase Ib/II PLX9486 + Sunitinib Pexidartinib + PLX9486 PLX9486 PLX9486 as a Single Agent and in Combination With PLX3397 or PLX9486 With Sunitinib in Patients With Advanced Solid Tumors Completed USA 0
NCT02406781 Phase II Cyclophosphamide + Pembrolizumab Cyclophosphamide + GLA-SE + Pembrolizumab Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial (PEMBROSARC) Unknown status FRA 0
NCT02508532 Phase I Avapritinib Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors Completed USA | POL | NLD | ITA | GBR | FRA | ESP | DEU | BEL 1
NCT02574663 Phase I Gemcitabine + Nab-paclitaxel Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Umbralisib TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors Completed USA 0
NCT02638766 Phase II Regorafenib Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST (REGISTRI) Completed ITA | FRA | ESP 0
NCT02847429 Phase III Crenolanib Randomized Trial of Crenolanib in Subjects With D842V Mutated GIST Unknown status USA | POL | NOR | ITA | FRA | ESP | DEU 0
NCT02880020 Phase II Nivolumab Ipilimumab + Nivolumab Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery Completed USA 0
NCT02992912 Phase II Atezolizumab Atezolizumab With Stereotactic Ablative Radiotherapy in Patients With Metastatic Tumours (SABR-PDL1) Active, not recruiting FRA 0
NCT03109301 Phase II Selumetinib A Phase II Trial of the Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Patients With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Withdrawn 0
NCT03158103 Phase I Binimetinib + Pexidartinib A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) Completed USA 0
NCT03165721 Phase II Guadecitabine A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer Terminated USA 0
NCT03291054 Phase II Epacadostat + Pembrolizumab Epacadostat and Pembrolizumab in Patients With GIST Terminated USA 0
NCT03353753 Phase III Ripretinib Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies (invictus) Completed USA | POL | NLD | ITA | GBR | FRA | FIN | ESP | DEU | CAN | BEL | AUS 1
NCT03411915 Phase I XmAb18087 A Study of XmAb18087 in Subjects With NET and GIST Completed USA 0
NCT03465722 Phase III Regorafenib Avapritinib (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST Completed USA | SWE | POL | NLD | ITA | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BEL | AUT | AUS 3
NCT03475953 Phase Ib/II Avelumab + Regorafenib A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors (REGOMUNE) Recruiting FRA 0
NCT03556384 Phase II Temozolomide Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) Active, not recruiting USA 0
NCT03673501 Phase III Sunitinib Ripretinib A Study of DCC-2618 vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib (intrigue) Active, not recruiting USA | SWE | POL | NOR | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BEL | AUS | ARG 4
NCT04000529 Phase I Spartalizumab + TNO155 Ribociclib + TNO155 Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies Terminated USA | ESP | DEU | BEL | AUS 4
NCT04138381 Phase Ib/II Imatinib + Selinexor Selinexor as a Single Agent and in Combination With Imatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors. (SeliGIST) Active, not recruiting ESP 0
NCT04193553 Phase II Lenvatinib Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure (LENVAGIST) Completed FRA 0
NCT04276415 Phase I DS-6157a DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST) Terminated USA 1
NCT04530981 Phase I Repaglinide + Ripretinib A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients With Advanced GIST Completed USA 0
NCT04595747 Phase II Rogaratinib Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST) Active, not recruiting USA 0
NCT04714983 Phase I DNX-2440 DNX-2440 for Resectable Colorectal Liver Metastasis Suspended USA 0
NCT04908176 Phase I Avapritinib + Midazolam A Drug-drug Interaction Study of Avapritinib and Midazolam Active, not recruiting USA 0
NCT04936178 Phase I NB003 A Study of NB003 in Patients With Advanced Malignancies Recruiting USA | GBR | FRA | ESP 2
NCT05006794 Phase I GS-9716 + Sacituzumab govitecan-hziy GS-9716 Docetaxel + GS-9716 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies Recruiting USA | ISR 0
NCT05009927 Phase II Imatinib Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten) Recruiting FRA 0
NCT05080621 Phase Ib/II Binimetinib + Ripretinib Ripretinib in Combination With Binimetinib in Patients With Gastrointestinal Stromal Tumor (GIST) Withdrawn 0
NCT05152472 Phase II Imatinib Atezolizumab + Imatinib A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments (ATEZOGIST) Recruiting FRA 0
NCT05160168 Phase Ib/II THE-630 A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) Terminated USA 0
NCT05208047 Phase III Sunitinib PLX9486 + Sunitinib PLX9486 (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors Recruiting USA | SWE | POL | NOR | NLD | ITA | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | AUS | ARG 5
NCT05245968 Phase I Imatinib Sunitinib Pimitespib Imatinib + Pimitespib A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101) Recruiting AUS 4
NCT05366816 Phase II Regorafenib Sunitinib ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST Recruiting USA 0
NCT05489237 Phase I IDRX-42 A First-in-human (FIH) Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) [Study ID: StrateGIST 1] Recruiting USA | ESP | DEU | BEL 0
NCT05493215 Phase II Imatinib Imatinib TDM in GIST Recruiting USA 0
NCT05734105 Phase III Ripretinib Sunitinib A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib (INSIGHT) Recruiting USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BRA | AUS 3
NCT05957367 Phase Ib/II DCC-3116 + Ripretinib Cetuximab + DCC-3116 + Encorafenib A Study of DCC-3116 in Combination With Anticancer Therapies in Participants With Advanced Malignancies Recruiting USA 0
NCT06087263 Phase II Regorafenib Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting. Recruiting USA 0
NCT06208748 Phase II PLX9486 + Sunitinib SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST Recruiting USA 0
NCT06630234 Phase Ib/II DCC-3009 A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST) Recruiting USA 0