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Molecular Profile | BRAF V600E BRAF amp |
Therapy | SCH772984 |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E BRAF amp | lung adenocarcinoma | decreased response | SCH772984 | Preclinical - Patient cell culture | Actionable | In a preclinical study, patient-derived BRAF V600E mutant lung adenocarcinoma cells that acquired resistance to Erk inhibitor through BRAF amplification were less sensitive to SCH772984 in culture (PMID: 28714990). | 28714990 |
PubMed Id | Reference Title | Details |
---|---|---|
(28714990) | An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer. | Full reference... |