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Molecular Profile | KIT wild-type |
Therapy | Avapritinib |
Indication/Tumor Type | acute megakaryocytic leukemia |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT wild-type | acute megakaryocytic leukemia | decreased response | Avapritinib | Preclinical - Cell culture | Actionable | In a preclinical study, KIT wild-type megakaryocytic leukemia cells were less sensitive to Ayvakit (avapritinib) compared to cells harboring KIT mutations in culture (PMID: 29093181). | 29093181 |
PubMed Id | Reference Title | Details |
---|---|---|
(29093181) | A precision therapy against cancers driven by KIT/PDGFRA mutations. | Full reference... |