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Molecular Profile EML4 - ALK ALK L1196M ALK G1269A
Therapy Crizotinib
Indication/Tumor Type lung non-small cell carcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK L1196M ALK G1269A lung non-small cell carcinoma predicted - resistant Crizotinib Case Reports/Case Series Actionable In a clinical study, a patient with non-small cell lung cancer harboring EML4-ALK demonstrated a partial response when treated with Xalkori (crizotinib), however, after 6 months the patient progressed and was found to harbor two secondary resistance mutations, ALK G1269A and ALK L1196M (PMID: 23344087). 23344087
PubMed Id Reference Title Details
(23344087) Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer. Full reference...