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| Molecular Profile | NTRK1 over exp |
| Therapy | GTx-186 |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 over exp | neuroblastoma | sensitive | GTx-186 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GTx-186 inhibited Erk signaling, resulted in growth inhibition of neuroblastoma cells overexpressing Ntrk1 in culture and in cell line xenograft models (PMID: 24386191). | 24386191 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24386191) | Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation. | Full reference... |