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| Molecular Profile | MDM2 over exp TP53 wild-type |
| Therapy | AQ-101 |
| Indication/Tumor Type | acute lymphoblastic leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 over exp TP53 wild-type | acute lymphoblastic leukemia | sensitive | AQ-101 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AQ-101 inhibited growth and induced apoptosis in acute lymphocytic leukemia (ALL) cell lines with wild-type TP53 and overexpression of MDM2 in culture, and inhibited development of leukemia in ALL cell line xenograft models (PMID: 29282301). | 29282301 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29282301) | Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. | Full reference... |