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Therapy Name AQ-101
Synonyms
Therapy Description

AQ-101 interferes with the interaction between MDM2 and MDM4 and induces degradation of MDM2, resulting in activation of Tp53, and potentially leading to decreased proliferation and increased apoptosis of tumor cells (PMID: 29282301).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AQ-101 AQ101|AQ 101 MDM2 Inhibitor 23 AQ-101 interferes with the interaction between MDM2 and MDM4 and induces degradation of MDM2, resulting in activation of Tp53, and potentially leading to decreased proliferation and increased apoptosis of tumor cells (PMID: 29282301).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MDM2 over exp TP53 wild-type acute lymphoblastic leukemia sensitive AQ-101 Preclinical - Cell line xenograft Actionable In a preclinical study, AQ-101 inhibited growth and induced apoptosis in acute lymphocytic leukemia (ALL) cell lines with wild-type TP53 and overexpression of MDM2 in culture, and inhibited development of leukemia in ALL cell line xenograft models (PMID: 29282301). 29282301

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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