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Molecular Profile RET L629P RET D631_R635delinsG RET V637R
Therapy Pralsetinib
Indication/Tumor Type medullary thyroid carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET L629P RET D631_R635delinsG RET V637R medullary thyroid carcinoma predicted - sensitive Pralsetinib Case Reports/Case Series Actionable In a Phase I trial, a patient with medullary thryoid cancer harboring RET D631_R635delinsG, L629P, and V637R demonstrated a partial response, with maximal tumor reduction of 47% at 10 months, following treatment with Gavreto (pralsetinib) (PMID: 29657135; NCT03037385). 29657135
PubMed Id Reference Title Details
(29657135) Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. Full reference...