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| Molecular Profile | CTNNB1 S45F |
| Therapy | Mps-BAY2b |
| Indication/Tumor Type | colorectal adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CTNNB1 S45F | colorectal adenocarcinoma | predicted - sensitive | Mps-BAY2b | Preclinical - Cell culture | Actionable | In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). | 28751540 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28751540) | TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers. | Full reference... |