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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Showing 1 to 28 of 28 entries

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CTNNB1 T41A	lung cancer	predicted - sensitive	NTRC 0066-0	Preclinical - Cell line xenograft	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1, in culture and in xenograft models (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	BAY1217389	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	Mps-BAY2b	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	Mps1-IN-1	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	NTRC 0066-0	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal carcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	MPI-0479605	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y demonstrated increased sensitivity to MPI-0479605 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	Mps1-IN-1	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	MPI-0479605	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del demonstrated increased sensitivity to MPI-0479605 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	BAY1217389	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colorectal adenocarcinoma	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	Mps-BAY2b	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	NTRC 0066-0	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1 or an isogenic cell line lacking the CTNNB1 mutation, in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	Mps-BAY2b	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	NTRC 0066-0	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal carcinoma cell line harboring CTNNB1 S45F, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	MPI-0479605	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F demonstrated increased sensitivity to MPI-0479605 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	BAY1217389	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	Mps1-IN-1	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	Mps1-IN-1	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	MPI-0479605	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A demonstrated increased sensitivity to MPI-0479605 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	Mps-BAY2b	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	BAY1217389	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540

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