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| Molecular Profile | MAP2K1 K57E |
| Therapy | Dabrafenib |
| Indication/Tumor Type | melanoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MAP2K1 K57E | melanoma | resistant | Dabrafenib | Preclinical | Actionable | In a preclinical study, MAP2K1 (MEK1) K57E mutations restored extracellular signal-regulated kinase (ERK) activation in the presence of Tafinlar (dabrafenib) in cultured melanoma cell lines (PMID: 24463458). | 24463458 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24463458) | BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. | Full reference... |