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| Molecular Profile | CSF1R Y571D |
| Therapy | Imatinib |
| Indication/Tumor Type | myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CSF1R Y571D | myeloid leukemia | sensitive | Imatinib | Preclinical | Actionable | In a preclinical study, CSF1R Y571D conferred sensitivity to Gleevec (imatinib) in myeloid cell lines in culture (PMID: 18971950). | 18971950 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18971950) | Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1. | Full reference... |