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| Molecular Profile | KIT V569_L576del KIT V654A KIT N822K |
| Therapy | Imatinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V569_L576del KIT V654A KIT N822K | gastrointestinal stromal tumor | predicted - resistant | Imatinib | Case Reports/Case Series | Actionable | In a clinical study, KIT V654A and KIT N822K were identified as secondary mutations in a patient with gastrointestinal stromal tumor harboring a primary KIT V569_L576del mutation, who developed resistance to Gleevec (imatinib) (PMID: 18488160). | 18488160 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18488160) | Molecular analysis of secondary kinase mutations in imatinib-resistant gastrointestinal stromal tumors. | Full reference... |