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Molecular Profile | BRAF V600E |
Therapy | Dasatinib |
Indication/Tumor Type | lung carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | lung carcinoma | resistant | Dasatinib | Preclinical | Actionable | In a preclinical study, Sprycel (dasatinib) failed to induce apoptosis in lung carcinoma cells expressing BRAF V600E (PMID: 22649091). | 22649091 |
PubMed Id | Reference Title | Details |
---|---|---|
(22649091) | Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. | Full reference... |