Profile Response Detail

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Molecular Profile TSC1 E636fs
Therapy Everolimus
Indication/Tumor Type bladder carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TSC1 E636fs bladder carcinoma sensitive Everolimus Case Reports/Case Series Actionable A retrospective study of a Phase II trial correlated increased sensitivity to the mTOR inhibitor Afinitor (everolimus) with TSC1 mutations in bladder cancer patients, including one patient harboring TSC1 E636fs* who had a durable complete response (PMID: 22923433). 22923433
PubMed Id Reference Title Details
(22923433) Genome sequencing identifies a basis for everolimus sensitivity. Full reference...