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| Molecular Profile | ARID1A loss |
| Therapy | unspecified PD-L1 antibody |
| Indication/Tumor Type | colon cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ARID1A loss | colon cancer | predicted - sensitive | unspecified PD-L1 antibody | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ARID1A-deficient colon cancer xenograft models demonstrated an increased response to treatment with an anti-PD-L1 antibody compared to controls (PMID: 29736026). | 29736026 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29736026) | ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. | Full reference... |