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Molecular Profile | ARID1A Q1148* |
Therapy | JQ1 |
Indication/Tumor Type | ovarian clear cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A Q1148* | ovarian clear cell carcinoma | predicted - sensitive | JQ1 | Preclinical - Pdx | Actionable | In a preclinical study, JQ1 inhibited tumor growth in an ovarian clear cell carcinoma patient-derived xenograft (PDX) model harboring ARID1A Q1148*, but did not inhibit growth in a model with wild-type ARID1A (PMID: 29760405). | 29760405 |
PubMed Id | Reference Title | Details |
---|---|---|
(29760405) | ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors. | Full reference... |