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Therapy Name	JQ1
Synonyms
Therapy Description	JQ1 is a BET bromodomain inhibitor with greatest specificity towards BRD4, resulting in decreased Myc expression, increased cell death, reduced macrophage immunosuppression, and inhibition of tumor growth (PMID: 24231268, PMID: 31018997, PMID: 30906568, PMID: 32800944).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
JQ1		JQ-1	BET Inhibitor (Pan) 32	JQ1 is a BET bromodomain inhibitor with greatest specificity towards BRD4, resulting in decreased Myc expression, increased cell death, reduced macrophage immunosuppression, and inhibition of tumor growth (PMID: 24231268, PMID: 31018997, PMID: 30906568, PMID: 32800944).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ARID1A Q1148*	ovarian clear cell carcinoma	predicted - sensitive	JQ1	Preclinical - Pdx	Actionable	In a preclinical study, JQ1 inhibited tumor growth in an ovarian clear cell carcinoma patient-derived xenograft (PDX) model harboring ARID1A Q1148*, but did not inhibit growth in a model with wild-type ARID1A (PMID: 29760405).	29760405
FBXW7 positive	adult T-cell leukemia/lymphoma	predicted - sensitive	JQ1	Preclinical - Cell line xenograft	Actionable	In a preclinical study, adult T cell leukemia cells expressing FBXW7 in a mouse model demonstrated decreased tumor volume when treated with JQ1 (PMID: 32907612).	32907612
ARID1A loss	ovarian clear cell carcinoma	predicted - sensitive	JQ1	Preclinical - Cell culture	Actionable	In a preclinical study, knockout of ARID1A in ovarian clear cell carcinoma cell lines resulted in increased sensitivity to growth inhibition by JQ1 compared to cells with wild-type ARID1A in culture (PMID: 29760405).	29760405
FBXW7 H468R	adult T-cell leukemia/lymphoma	resistant	JQ1	Preclinical - Cell culture	Actionable	In a preclinical study, adult T cell leukemia cells expressing FBXW7 H468R were resistant to treatment with JQ1 in culture (PMID: 32907612).	32907612
FBXW7 S462P	adult T-cell leukemia/lymphoma	resistant	JQ1	Preclinical - Cell culture	Actionable	In a preclinical study, adult T cell leukemia cells expressing FBXW7 S462P treated with JQ1 demonstrated resistance in both short term and long term culture, and showed increased phosphorylation of Braf, Mek, and Erk, and increased expression of Stat3 and Myc (PMID: 32907612).	32907612
FBXW7 W425R	adult T-cell leukemia/lymphoma	resistant	JQ1	Preclinical - Cell culture	Actionable	In a preclinical study, adult T cell leukemia cells expressing FBXW7 W425R demonstrated resistance to treatment with JQ1 in culture (PMID: 32907612).	32907612
RB1 del	prostate cancer	sensitive	JQ1	Preclinical	Actionable	In a preclinical study, JQ1 treatment inhibited tumor growth in a syngeneic mouse model of RB1-deficient prostate cancer (PMID: 37014264).	37014264
TP53 mutant	medulloblastoma	decreased response	JQ1	Preclinical	Actionable	In a preclinical study, medulloblastoma cell lines with TP53 mutations had significantly less sensitivity to the BET inhibitor, JQ1, than cell lines carrying wild-type TP53 (PMID: 24231268).	24231268
TP53 wild-type	medulloblastoma	sensitive	JQ1	Preclinical	Actionable	In a preclinical study, medulloblastoma cell lines with TP53 mutations had significantly less sensitivity to the BET inhibitor, JQ1, than cell lines carrying wild-type TP53 (PMID: 24231268).	24231268

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