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| Molecular Profile | PTEN wild-type |
| Therapy | 2-Methoxyestradiol |
| Indication/Tumor Type | glioblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN wild-type | glioblastoma | sensitive | 2-Methoxyestradiol | Preclinical | Actionable | In a preclinical study, 2-Methoxyestradiol (2ME2) inhibited tumor-induced angiogenesis and reduced tumor growth in PTEN reconstituted GBM cell lines and mouse models (PMID: 24162827). | 24162827 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24162827) | PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. | Full reference... |