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Molecular Profile | PTEN wild-type |
Therapy | 2-Methoxyestradiol |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN wild-type | glioblastoma | sensitive | 2-Methoxyestradiol | Preclinical | Actionable | In a preclinical study, 2-Methoxyestradiol (2ME2) inhibited tumor-induced angiogenesis and reduced tumor growth in PTEN reconstituted GBM cell lines and mouse models (PMID: 24162827). | 24162827 |
PubMed Id | Reference Title | Details |
---|---|---|
(24162827) | PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. | Full reference... |