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| Molecular Profile | BRAF V600E |
| Therapy | Dabrafenib |
| Indication/Tumor Type | colon neuroendocrine neoplasm |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colon neuroendocrine neoplasm | predicted - sensitive | Dabrafenib | Case Reports/Case Series | Actionable | In a clinical case study, Tafinlar (dabrafenib) treatment of a patient with recurrent neuroendocrine carcinoma of the colon harboring a BRAF V600E mutation resulted in stable disease for 6 months before disease progression (PMID: 30181415). | 30181415 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30181415) | Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon. | Full reference... |