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Molecular Profile | FLT3 exon 14 ins |
Therapy | Sorafenib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Sorafenib | Phase II | Actionable | In a Phase II trial (SORMAIN), maintenance treatment with Nexavar (sorafenib) following hematopoietic stem cell transplantation in patients with acute myeloid leukemia harboring a FLT3 internal tandem duplication (FLT3-ITD) mutation (n=43) resulted in a median relapse-free survival (RFS) that was not reached vs 30.9 mo in the placebo arm (n=40) at a median follow-up of 41.8 mo (HR=0.39, p=0.013), and the estimated probability of 24-mo RFS was 85.0% vs 53.3% (HR=0.255, p=0.002) (PMID: 32673171). | 32673171 |
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation and growth of acute myeloid leukemia cell lines harboring FLT3 exon 14 insertions (ITD) in culture (PMID: 31309543). | 31309543 |
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Sorafenib | Preclinical - Patient cell culture | Actionable | In a preclinical study, FLT3-ITD mutations correlated with sensitivity to Nexavar (sorafenib) in patient-derived acute myeloid leukemia samples in an ex vivo assay (PMID: 30333627). | 30333627 |
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Sorafenib | Guideline | Actionable | Nexavar (sorafenib) is included in guidelines as maintenance therapy for patients with acute myeloid leukemia harboring a FLT3 internal tandem duplication (FLT3-ITD) mutation (NCCN.org). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
NCCN.org | Full reference... | |
(30333627) | Functional genomic landscape of acute myeloid leukaemia. | Full reference... |
(31309543) | Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies. | Full reference... |
(32673171) | Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3-Internal Tandem Duplication Mutation (SORMAIN). | Full reference... |