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| Molecular Profile | ATM T1200Lfs*7 NRAS Q61K TP53 R213* |
| Therapy | Olaparib |
| Indication/Tumor Type | sarcoma |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM T1200Lfs*7 NRAS Q61K TP53 R213* | sarcoma | predicted - resistant | Olaparib | Case Reports/Case Series | Actionable | In a clinical case study, Lynparza (olaparib) treatment resulted in rapid disease progression in a patient with high-grade sarcoma harboring ATM T1200Lfs*7, NRAS Q61K, and TP53 R213* (PMID: 29304353). | 29304353 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29304353) | Yale Cancer Center Precision Medicine Tumor Board: two patients, one targeted therapy, different outcomes. | Full reference... |