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| Molecular Profile | TP53 R280M |
| Therapy | Nutlin-3a |
| Indication/Tumor Type | osteosarcoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R280M | osteosarcoma | resistant | Nutlin-3a | Preclinical | Actionable | In a preclinical study, TP53 R280M resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018). | 21643018 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21643018) | Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3. | Full reference... |