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Therapy Name	Nutlin-3a
Synonyms
Therapy Description	Nutlin-3a is an MDM2 inhibitor that activates p53, potentially resulting in induction of apoptosis and senescence in tumor cells (PMID: 18451145, PMID: 32653500).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Nutlin-3a		Nutlin\|Nutlin-3	MDM2 Inhibitor 23	Nutlin-3a is an MDM2 inhibitor that activates p53, potentially resulting in induction of apoptosis and senescence in tumor cells (PMID: 18451145, PMID: 32653500).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 R181E	Advanced Solid Tumor	no benefit	Nutlin-3a	Preclinical - Cell culture	Actionable	In a preclinical study, Nutlin-3 treatment did not reduce cell proliferation and viability in transformed mouse cells expressing TP53 R181E in culture (PMID: 31483066).	31483066
RB1 inact mut	retinoblastoma	sensitive	Nutlin-3a	Preclinical	Actionable	In a preclinical study, Nutlin-3a induced p53 pathway signaling in MDMX mouse models with retinoblastoma and 69% (70/102) of the eyes harvested from the mouse models demonstrated complete response or stable disease after 18 weeks of therapy (PMID: 21515735).	21515735
TP53 del	ovarian cancer	no benefit	Nutlin-3a	Preclinical	Actionable	In a preclinical study, treatment with Nutlin-3 had little effect on growth of ovarian cancer cells with deletion of TP53 in culture (PMID: 25964101).	25964101
TP53 E258Q	osteosarcoma	resistant	Nutlin-3a	Preclinical	Actionable	In a preclinical study, TP53 E258Q resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018).	21643018
TP53 I232S	osteosarcoma	resistant	Nutlin-3a	Preclinical	Actionable	In a preclinical study, TP53 I232S resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018).	21643018
TP53 mutant	neuroblastoma	resistant	Nutlin-3a	Preclinical	Actionable	In a preclinical study, neuroblastoma cell lines harboring TP53 mutant were resistant to nutlin-3 mediated growth inhibition (PMID: 21725357).	21725357
TP53 mutant	ovarian cancer	no benefit	Nutlin-3a	Preclinical	Actionable	In a preclinical study, treatment with Nutlin-3 had little effect on growth of ovarian cancer cells with TP53 mutations in culture (PMID: 25964101).	25964101
TP53 P177T	osteosarcoma	resistant	Nutlin-3a	Preclinical	Actionable	In a preclinical study, TP53 P177T resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018).	21643018
TP53 R280M	osteosarcoma	resistant	Nutlin-3a	Preclinical	Actionable	In a preclinical study, TP53 R280M resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018).	21643018

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