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Molecular Profile | ATM R2691C |
Therapy | Olaparib |
Indication/Tumor Type | neuroblastoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM R2691C | neuroblastoma | no benefit | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, Lynparza (olaparib) treatment of transformed neuroblastoma cells expressing ATM R2691C resulted in similar cell viability levels to wild-type Atm in culture (PMID: 29059438). | 29059438 |
PubMed Id | Reference Title | Details |
---|---|---|
(29059438) | Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. | Full reference... |