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| Molecular Profile | FLT3 D835Y IDH1 R132H |
| Therapy | AGI-5198 |
| Indication/Tumor Type | hematologic cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 D835Y IDH1 R132H | hematologic cancer | resistant | AGI-5198 | Preclinical - Cell culture | Actionable | In a preclinical study, AGI-5198 treatment did not decrease proliferation of transformed cells expressing FLT3 D835Y and IDH1 R132H in culture (PMID: 30651561). | 30651561 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30651561) | Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. | Full reference... |