Therapy Detail
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| Therapy Name | AGI-5198 |
| Synonyms | |
| Therapy Description |
AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169, PMID: 26368816, PMID: 31151327). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AGI-5198 | AG5198|AGI 5198|IDH-C35 | IDH1 Inhibitor 8 | AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169, PMID: 26368816, PMID: 31151327). |
Filtering
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132C | high grade glioma | sensitive | AGI-5198 | Preclinical | Actionable | In a preclinical study, AGI-5198 inhibited growth and promoted differentiation in glioma cells expressing IDH1 R132C (PMID: 23558169). | 23558169 |
| FLT3 D835Y IDH1 R132H | hematologic cancer | resistant | AGI-5198 | Preclinical - Cell culture | Actionable | In a preclinical study, AGI-5198 treatment did not decrease proliferation of transformed cells expressing FLT3 D835Y and IDH1 R132H in culture (PMID: 30651561). | 30651561 |
| FLT3 D835Y IDH1 wild-type | hematologic cancer | resistant | AGI-5198 | Preclinical - Cell culture | Actionable | In a preclinical study, AGI-5198 treatment did not decrease proliferation of transformed cells expressing FLT3 D835Y and IDH1 wild-type in culture (PMID: 30651561). | 30651561 |
| IDH1 R132H | high grade glioma | sensitive | AGI-5198 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AGI-5198 inhibited growth of a glioma cell line harboring IDH1 R132H in culture and in xenograft models (PMID: 23558169). | 23558169 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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