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| Molecular Profile | MERTK positive |
| Therapy | RGX-019 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MERTK positive | Advanced Solid Tumor | predicted - sensitive | RGX-019 | Preclinical - Cell culture | Actionable | In a preclinical study, RGX-019 treatment induced Mertk internalization and degradation in tumor cell lines, leading to inhibition of colony formation in culture (AACR Annual Meeting 2019, Abstract LB-277). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Characterization of the anti-cancer and immunologic activity of RGX-019, a novel pre-clinical stage humanized monoclonal antibody targeting the MERTK receptor | Full reference... |