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Molecular Profile | FLT3 D835X |
Therapy | Cytarabine + Daunorubicin + Midostaurin |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D835X | acute myeloid leukemia | sensitive | Cytarabine + Daunorubicin + Midostaurin | FDA approved - On Companion Diagnostic | Actionable | In a Phase III trial that supported FDA approval, treatment with Rydapt (midostaurin), combined with Cytosar-U (cytarabine) and Daunorubicin, improved overall survival (74.7 mo vs 25.6 mo) in patients with FLT3-mutant (D835X and I836X) or FLT3-ITD (exon 14 insertions) acute myeloid leukemia compared to Cytosar-U (cytarabine) and Daunorubicin with placebo (PMID: 28644114). | detail... 28644114 detail... |
PubMed Id | Reference Title | Details |
---|---|---|
(28644114) | Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation. | Full reference... |
Full reference... | ||
Rydapt (midostaurin) FDA Drug Label | Full reference... |