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| Molecular Profile | MAP2K1 V211D |
| Therapy | Cobimetinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MAP2K1 V211D | Advanced Solid Tumor | predicted - resistant | Cobimetinib | Preclinical - Biochemical | Actionable | In a preclinical study, Cotellic (cobimetinib) did not inhibit kinase activity of MAP2K1 V211D in an in vitro assay (PMID: 31227518). | 31227518 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31227518) | V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. | Full reference... |