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Molecular Profile | FLT3 R595_L601dup |
Therapy | Tandutinib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 R595_L601dup | acute myeloid leukemia | sensitive | Tandutinib | Preclinical | Actionable | In a preclinical study, tandutinib (CT53518) inhibited cell proliferation in cell culture and in mouse models carrying FLT3 L601_K602insREYEYDL (PMID: 12124172). | 12124172 |
PubMed Id | Reference Title | Details |
---|---|---|
(12124172) | CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). | Full reference... |