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| Molecular Profile | KIT V560G KIT D816V |
| Therapy | Regorafenib |
| Indication/Tumor Type | mast cell neoplasm |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560G KIT D816V | mast cell neoplasm | resistant | Regorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, mast cells harboring both KIT D816V and KIT V560G were resistant to Stivarga (regorafenib) in culture (PMID: 31085175). | 31085175 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31085175) | Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. | Full reference... |