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ID | DOID:3664 |
Name | mast cell neoplasm |
Definition | A hematologic cancer that has_material_basis_in mast cells. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer hematologic cancer mast cell neoplasm |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
KIT V560G KIT D816V | Quizartinib | mast cell neoplasm | resistant | detail... |
KIT D816Y | Ripretinib | mast cell neoplasm | predicted - sensitive | detail... |
KIT D816Y | Avapritinib | mast cell neoplasm | predicted - sensitive | detail... |
KIT D816V | Avapritinib | mast cell neoplasm | predicted - sensitive | detail... |
KIT D816Y | Imatinib | mast cell neoplasm | predicted - resistant | detail... |
KIT D816Y | Sunitinib | mast cell neoplasm | decreased response | detail... |
KIT D816Y | Regorafenib | mast cell neoplasm | predicted - resistant | detail... |
KIT D816Y | Midostaurin | mast cell neoplasm | predicted - sensitive | detail... |
KIT V560G | Ripretinib | mast cell neoplasm | sensitive | detail... |
KIT V560G | Imatinib | mast cell neoplasm | sensitive | detail... |
KIT V560G | Sunitinib | mast cell neoplasm | sensitive | detail... |
KIT V560G | Regorafenib | mast cell neoplasm | sensitive | detail... |
KIT V560G | Midostaurin | mast cell neoplasm | sensitive | detail... |
KIT V560G | Avapritinib | mast cell neoplasm | sensitive | detail... |
KIT V560G KIT D816V | Ripretinib | mast cell neoplasm | sensitive | detail... |
KIT V560G KIT D816V | Midostaurin | mast cell neoplasm | sensitive | detail... |
KIT V560G KIT D816V | Avapritinib | mast cell neoplasm | sensitive | detail... |
KIT V560G KIT D816V | Imatinib | mast cell neoplasm | resistant | detail... |
KIT V560G KIT D816V | Sunitinib | mast cell neoplasm | resistant | detail... |
KIT V560G KIT D816V | Regorafenib | mast cell neoplasm | resistant | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT02415608 | Phase II | Ibrutinib | Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis | Terminated | USA | 0 |
NCT02561988 | Phase I | Avapritinib | (EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies | Completed | USA | GBR | 0 |