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| Molecular Profile | CDKN2A del |
| Therapy | Palbociclib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CDKN2A del | gastrointestinal stromal tumor | no benefit | Palbociclib | Phase II | Actionable | In a Phase II trial, Ibrance (palbociclib) treatment did not demonstrated clinical efficacy in heavily pre-treated gastrointestinal stromal tumor patients harboring CDKN2A homozygous or heterozygous deletion, with 86.4% (19/22) of patients demonstrated progressive disease at 4 months (PMID: 30979737; NCT01907607). | 30979737 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30979737) | Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study. | Full reference... |