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| Molecular Profile | APC Q1406* |
| Therapy | XAV939 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC Q1406* | colorectal cancer | predicted - sensitive | XAV939 | Preclinical | Actionable | In a preclinical study, XAV939 treatment inhibited growth of mouse intestinal organoids expressing APC Q1045* (corresponding to Q1046* in human) in culture (PMID: 31337618). | 31337618 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31337618) | Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. | Full reference... |