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| Molecular Profile | NTRK1 over exp |
| Therapy | GW441756 |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 over exp | neuroblastoma | sensitive | GW441756 | Preclinical | Actionable | In a preclinical study, GW441756, a TrkA inhibitor, blocked tyrosine phosphorylation of ERK and JNK induced by TrkA over expression in neuroblastoma cells (PMID: 23319303). | 23319303 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23319303) | Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells. | Full reference... |