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| Molecular Profile | PTEN loss |
| Therapy | CYH33 |
| Indication/Tumor Type | breast cancer |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | breast cancer | no benefit | CYH33 | Preclinical - Cell culture | Actionable | In a preclinical study, PTEN loss was not associated with sensitivity to CYH33 in breast cancer cell lines in culture (PMID: 30003928). | 30003928 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30003928) | Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer. | Full reference... |