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| Molecular Profile | MDM2 M62A |
| Therapy | Nutlin-3a |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 M62A | Advanced Solid Tumor | predicted - resistant | Nutlin-3a | Preclinical - Biochemical | Actionable | In a preclinical study, MDM2 M62A conferred resistance to Nutlin-3a as demonstrated by decreased restoration of Tp53 activity in reporter assays in culture, and impaired inhibition of Mdm2-Tp53 interaction in in vitro assays (PMID: 23653682). | 23653682 |
| MDM2 M62A | Advanced Solid Tumor | predicted - resistant | Nutlin-3a | Preclinical - Biochemical | Actionable | In a preclinical study, MDM2 M62A conferred resistance to Nutlin-3a as demonstrated by decreased restoration of Tp53 activity in a reporter assay and decreased inhibition of the Mdm2-Tp53 interaction in culture (PMID: 24278380). | 24278380 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23653682) | In vitro selection of mutant HDM2 resistant to Nutlin inhibition. | Full reference... |
| (24278380) | Inhibition of nutlin-resistant HDM2 mutants by stapled peptides. | Full reference... |