Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | STK11 wild-type |
Therapy | Metformin |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
STK11 wild-type | Advanced Solid Tumor | sensitive | Metformin | Preclinical - Cell culture | Actionable | In a preclinical studies, Glucophage (metformin) inhibited cancer cell growth by activating the AMP kinase pathway in a variety of cancer cell lines that retained one functional allele of STK11 (PMID: 17062558, PMID: 18006825). | 18006825 17062558 |
PubMed Id | Reference Title | Details |
---|---|---|
(18006825) | Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. | Full reference... |
(17062558) | Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. | Full reference... |