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Therapy Name | Metformin |
Synonyms | |
Therapy Description |
Glucophage (metformin) inhibits part of the mitochondrial respiratory chain and may exert antineoplastic effects through inhibition of mTOR and is FDA approved for type 2 diabetes (FDA.gov). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Metformin | Glucophage | Apo-Metformin | mTOR Inhibitor 51 | Glucophage (metformin) inhibits part of the mitochondrial respiratory chain and may exert antineoplastic effects through inhibition of mTOR and is FDA approved for type 2 diabetes (FDA.gov). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | colorectal cancer | sensitive | Metformin | Preclinical | Actionable | In a preclinical study, colorectal carcinoma cells expressing IDH1 R132H were sensitive to Glucophage (metformin), resulting in decreased cell proliferation in culture (PMID: 26363012). | 26363012 |
PIK3CA H1047R | colorectal cancer | sensitive | Metformin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Glucophage (metformin) demonstrated efficacy in treating dietary restriction-resistant human colorectal cancer cell line xenograft tumors harboring PIK3CA H1047R (PMID: 23986086). | 23986086 |
PTEN del | urinary bladder cancer | sensitive | Metformin | Preclinical | Actionable | In a preclinical study, bladder cancer cells with PTEN deletion were sensitive to Glucophage (metformin) in culture, resulting in inhibition of cell growth (PMID: 26921394). | 26921394 |
PIK3CA act mut | Advanced Solid Tumor | sensitive | Metformin | Preclinical | Actionable | In a preclinical study, Glucophage (metformin) demonstrated efficacy in treating dietary restriction-resistant human xenograft tumors harboring a PIK3CA-activating mutation (PMID: 23986086). | 23986086 |
HRAS mutant | urinary bladder cancer | sensitive | Metformin | Preclinical | Actionable | In a preclinical study, mouse models of bladder cancer harboring an HRAS mutation were sensitive to Glucophage (metformin), resulting in tumor growth reduction and prevention of hyperplasia regression (PMID: 26921394). | 26921394 |
TSC1 del | urinary bladder cancer | sensitive | Metformin | Preclinical | Actionable | In a preclinical study, bladder cancer cells harboring a deletion of TSC1 were sensitive to Glucophage (metformin) in culture, resulting in cell growth inhibition (PMID: 26921394). | 26921394 |
PIK3CA H1047R | breast cancer | sensitive | Metformin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Glucophage (metformin) inhibited cell proliferation of a dietary restriction-resistant PIK3CA H1047R-harboring human breast cancer cell line in culture, and inhibited tumor growth in xenograft models (PMID: 23986086). | 23986086 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT02531308 | Phase II | Metformin Cyclophosphamide + Doxorubicin + Prednisone + Vincristine Sulfate Pegfilgrastim Rituximab | Metformin in Combination With Standard Induction Therapy for Large B-cell Lymphoma (DLBCL) | Terminated | USA | 0 |
NCT02780024 | Phase II | Metformin | Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM | Active, not recruiting | CAN | 0 |
NCT02402348 | Phase I | Metformin | Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis | Terminated | USA | 0 |
NCT02115464 | Phase II | Metformin | Advanced Lung Cancer Treatment With Metformin and Chemo-Radiotherapy | Terminated | CAN | 0 |
NCT01793948 | Phase I | Metformin | Metformin Hydrochloride vs. Placebo in Overweight or Obese Patients at Elevated Risk for Breast Cancer | Completed | USA | 0 |
NCT01797523 | Phase II | Letrozole Everolimus Metformin | RAD/Letrozole/Metformin | Active, not recruiting | USA | 0 |
NCT01579812 | Phase II | Metformin | Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients | Completed | USA | 0 |
NCT02614859 | Phase II | Bicalutamide Metformin | Bicalutamide With or Without Metformin for Biochemical Recurrence in Overweight or Obese Prostate Cancer Patients | Completed | USA | 0 |
NCT02376166 | Phase I | Metformin | Metformin for Rising PSA Remote Trial | Completed | USA | 0 |
NCT04758000 | Phase II | Metformin | Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse (Metform-Bone) | Recruiting | ITA | 0 |
NCT02176161 | Phase II | Metformin | Metformin Prostate Cancer Adjuvant Trial | Completed | USA | 0 |
NCT01717482 | Phase II | Metformin | Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer | Terminated | USA | 0 |
NCT01750567 | Phase II | Metformin | A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL | Active, not recruiting | USA | 0 |
NCT02083692 | Phase I | Metformin | Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling | Completed | USA | 0 |
NCT02019979 | Phase II | Metformin | Metformin and Carbohydrate Restriction With Platinum Based Chemotherapy In Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NS-NSCLC) (METRO) | Terminated | USA | 0 |
NCT02285855 | Phase II | Metformin | Metformin in Non Small Cell Lung Cancer (NSCLC) | Terminated | USA | 0 |
NCT02048384 | Phase Ib/II | Metformin + Sirolimus Metformin | A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer | Completed | USA | 0 |
NCT02153450 | Phase I | Metformin | Stereotactic Radiosurgery and Metformin Hydrochloride in Treating Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer | Completed | USA | 0 |
NCT03477162 | Phase 0 | Metformin | Metformin Pharmacology in Human Cancers: A Proof of Principle Study | Terminated | USA | 0 |
NCT03053544 | Phase II | Metformin | Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Responses in Rectal Cancer | Completed | CAN | 0 |
NCT02815397 | Phase II | Metformin | DA-EPOCH-Rituximab/Metformin (RM) for Double Hit Lymphoma | Terminated | USA | 0 |
NCT01324180 | Phase I | Metformin Dexamethasone + Doxorubicin + Pegaspargase + Vincristine Sulfate | Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) | Completed | USA | 0 |
NCT02420652 | Phase II | Metformin | Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy | Terminated | USA | 0 |
NCT02040376 | Phase III | Metformin | Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma | Completed | CAN | 0 |
NCT02437812 | Phase II | Paclitaxel Carboplatin Metformin | Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma | Unknown status | USA | 0 |
NCT01578551 | Phase II | Metformin Carboplatin + Paclitaxel Bevacizumab | A Randomized Phase II Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma. | Terminated | USA | 0 |
NCT01666730 | Phase II | Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Metformin | Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer | Completed | USA | 0 |
NCT01488552 | Phase Ib/II | Oxaliplatin Fluorouracil + Irinotecan + Leucovorin Gemcitabine + Nab-paclitaxel Metformin | Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer | Completed | USA | 0 |
NCT03109873 | Phase I | Metformin | Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer | Completed | USA | 0 |
NCT01620593 | Phase II | Metformin | Castration Compared to Castration Plus Metformin as First Line Treatment for Patients With Advanced Prostate Cancer | Completed | USA | 0 |
NCT01996696 | Phase II | Metformin | A Study With or Without Metformin to Determine if Metformin Can Prevent Weight Gain and Other Problems (i.e. Diabetes, Increased Cholesterol, Etc.) That Can Arise From the Use of Hormonal Therapy in Combination With Radiation Therapy When Treating Aggressive Localized Prostate Cancer. | Terminated | CAN | 0 |
NCT02035787 | Phase I | Metformin | Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients | Completed | USA | 0 |
NCT03086733 | Phase II | Metformin | Phase II Lung Metcore - Preoperative Metformin for Lung Cancer (Metcore) | Completed | CAN | 0 |
NCT02278965 | Phase I | Metformin | Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer | Completed | USA | 0 |
NCT01302379 | Phase I | Metformin | Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors | Completed | USA | 0 |
NCT01340300 | Phase II | Metformin | Exercise and Metformin in Colorectal and Breast Cancer Survivors | Completed | USA | 0 |
NCT03076281 | Phase II | Doxycycline Doxycycline + Metformin Metformin | Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery | Active, not recruiting | USA | 0 |
NCT02122185 | Phase II | Metformin Carboplatin + Docetaxel + Paclitaxel | Metformin Hydrochloride and Combination Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Active, not recruiting | USA | 0 |
NCT01697566 | Phase III | Metformin | An Endometrial Cancer Chemoprevention Study of Metformin | Completed | USA | 0 |
NCT02978547 | Phase II | Metformin | The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma (Metformin 001) | Unknown status | CAN | 0 |
NCT02394652 | Phase II | Cisplatin Metformin | The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer | Completed | CAN | 0 |
NCT01877564 | Phase II | Metformin | A Randomized Pilot Study to Evaluate the Effects of a Short Course of Metformin Versus No Therapy in the Period Prior to Hysterectomy for Grade 1-2 Adenocarcinoma of the Endometrium in Obese Non-Diabetic Women | Completed | USA | 0 |
NCT02042495 | Phase II | Metformin | Endometrial Cancer Biomarker Changes Following Exposure to Metformin | Withdrawn | CAN | 0 |
NCT01528046 | Phase I | Metformin Irinotecan + Temozolomide + Vincristine Sulfate | Metformin in Children With Relapsed or Refractory Solid Tumors | Completed | USA | 0 |
NCT04691960 | Phase II | Metformin | A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging | Recruiting | USA | 0 |
NCT03379909 | Phase II | Metformin | Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer (TROJAN) | Recruiting | NLD | 0 |
NCT01954732 | Phase I | Metformin | Metformin Hydrochloride in Treating Patients With Pancreatic Cancer That Can be Removed by Surgery | Withdrawn | 0 | |
NCT01310231 | Phase II | Metformin | A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer | Completed | CAN | 0 |
NCT02186847 | Phase II | Metformin Carboplatin + Paclitaxel | Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer | Active, not recruiting | USA | ISR | CAN | 0 |
NCT01864096 | Phase III | Metformin | The Metformin Active Surveillance Trial (MAST) Study | Active, not recruiting | CAN | 0 |
NCT05929495 | Phase II | Metformin + Temozolomide Metformin | Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma | Not yet recruiting | ITA | 0 |
NCT04536805 | Phase Ib/II | Metformin | Relapse in Previously Irradiated Prostate Bed : Stereotactic Ablative Reirradiation Potentiated by Metformin (REPAIRGETUGP16) | Recruiting | FRA | 0 |
NCT00268476 | Phase II | Abiraterone + Prednisolone Metformin Abiraterone + Enzalutamide + Prednisolone Celecoxib Estradiol Zoledronic acid Docetaxel + Prednisolone Docetaxel + Prednisolone + Zoledronic acid Celecoxib + Zoledronic acid | Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) | Active, not recruiting | GBR | CHE | 0 |