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Molecular Profile | TP53 Y220C |
Therapy | SLMP53-2 |
Indication/Tumor Type | hepatocellular carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 Y220C | hepatocellular carcinoma | sensitive | SLMP53-2 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with SLMP53-2 induced cell-cycle arrest and apoptosis and inhibited growth, and resulted in restored Tp53 transcriptional activity in a hepatocellular carcinoma cell line harboring TP53 Y220C in culture, and inhibited tumor growth in xenograft models (PMID: 31405179). | 31405179 |
PubMed Id | Reference Title | Details |
---|---|---|
(31405179) | SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. | Full reference... |