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Therapy Detail
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| Therapy Name | SLMP53-2 |
| Synonyms | |
| Therapy Description |
SLMP53-2 is a compound that reactivates mutant Tp53, potentially resulting in decreased tumor cell growth (PMID: 31405179). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SLMP53-2 | p53 Activator 11 | SLMP53-2 is a compound that reactivates mutant Tp53, potentially resulting in decreased tumor cell growth (PMID: 31405179). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 G245S | lung non-small cell carcinoma | sensitive | SLMP53-2 | Preclinical - Cell culture | Actionable | In a preclinical study, SLMP53-2 inhibited growth of a non-small cell lung carcinoma cell line expressing TP53 G245S in culture (PMID: 31405179). | 31405179 |
| TP53 Y220C | lung non-small cell carcinoma | sensitive | SLMP53-2 | Preclinical - Cell culture | Actionable | In a preclinical study, SLMP53-2 inhibited growth of a non-small cell lung carcinoma cell line expressing TP53 Y220C in culture (PMID: 31405179). | 31405179 |
| TP53 Y220C | hepatocellular carcinoma | sensitive | SLMP53-2 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with SLMP53-2 induced cell-cycle arrest and apoptosis and inhibited growth, and resulted in restored Tp53 transcriptional activity in a hepatocellular carcinoma cell line harboring TP53 Y220C in culture, and inhibited tumor growth in xenograft models (PMID: 31405179). | 31405179 |
| TP53 R175H | lung non-small cell carcinoma | sensitive | SLMP53-2 | Preclinical - Cell culture | Actionable | In a preclinical study, SLMP53-2 inhibited growth of a non-small cell lung carcinoma cell line expressing TP53 R175H in culture (PMID: 31405179). | 31405179 |
| TP53 Y220C | breast ductal carcinoma | sensitive | SLMP53-2 | Preclinical - Cell culture | Actionable | In a preclinical study, SLMP53-2 treatment inhibited growth of a breast ductal carcinoma cell line harboring TP53 Y220C and resulted in increased expression of the Tp53 targets MDM2, p21, and KILLER and decreased expression of Survivin and VEGF in culture (PMID: 31405179). | 31405179 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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