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| Molecular Profile | PALB2 P8L |
| Therapy | Olaparib |
| Indication/Tumor Type | osteosarcoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PALB2 P8L | osteosarcoma | sensitive | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, osteosarcoma cells expressing PALB2 P8L were sensitive to treatment with Lynparza (olaparib), demonstrating decreased cell growth in culture (PMID: 31586400). | 31586400 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31586400) | A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor. | Full reference... |